Assay Detail
Binding
CHEMBL3771809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of rabbit muscle glycogen phosphorylase-b using alpha-D-glucose-1-phosphate as substrate by Dixon plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.16 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770455 | — | — | 1 | 7.51 |
| CHEMBL3770514 | — | — | 1 | 6.55 |
| CHEMBL560324 | — | — | 1 | 4.42 |
| CHEMBL3769528 | — | — | 1 | - |
| CHEMBL3770888 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770455 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3770514 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL560324 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL3769528 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL3770888 | — | Ki | = | 158000.0 | nM | - |