Assay Detail
Binding
CHEMBL3772467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.19 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041319 | — | — | 1 | 6.05 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.79 |
| CHEMBL3770480 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041319 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL660 | AMANTADINE | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL3770480 | — | IC50 | = | 18700.0 | nM | 4.73 |