Assay Detail
Functional
CHEMBL3772618
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Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 96 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.70 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770137 | — | — | 1 | 5.27 |
| CHEMBL3771045 | — | — | 1 | 4.50 |
| CHEMBL3769913 | — | — | 1 | 4.34 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | - |
| CHEMBL272195 | EPIANDROSTERONE | — | 1 | - |
| CHEMBL3769728 | — | — | 1 | - |
| CHEMBL3770683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770137 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL3771045 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL3769913 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL90593 | PRASTERONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL272195 | EPIANDROSTERONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL3769728 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3770683 | — | IC50 | > | 50000.0 | nM | - |