Assay Detail
ADMET
CHEMBL3772620
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Cytotoxicity against HAF assessed as reduction in cell viability after 96 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HAF |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.16 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.17 |
| CHEMBL3770805 | — | — | 1 | 5.74 |
| CHEMBL3770137 | — | — | 1 | 5.53 |
| CHEMBL3769630 | — | — | 1 | 4.75 |
| CHEMBL3769913 | — | — | 1 | 4.68 |
| CHEMBL3770246 | — | — | 1 | 4.58 |
| CHEMBL3771045 | — | — | 1 | 4.44 |
| CHEMBL3770683 | — | — | 1 | 4.41 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | - |
| CHEMBL3770372 | — | — | 1 | - |
| CHEMBL3770168 | — | — | 1 | - |
| CHEMBL3771344 | — | — | 1 | - |
| CHEMBL3769515 | — | — | 1 | - |
| CHEMBL3771030 | — | — | 1 | - |
| CHEMBL3770344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3770805 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3770137 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3769630 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3769913 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL3770246 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL3771045 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3770683 | — | IC50 | = | 39050.0 | nM | 4.41 |
| CHEMBL90593 | PRASTERONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL3770372 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3770168 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3771344 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3769515 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3771030 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3770344 | — | IC50 | > | 50000.0 | nM | - |