Assay Detail
Binding
CHEMBL3772777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human Adenosine A1 receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphai1 after 16 hrs by beta galactosidase reporter gene assay
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.62 | 6.70 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284969 | — | — | 1 | 6.70 |
| CHEMBL3770310 | — | — | 1 | 6.50 |
| CHEMBL116903 | — | — | 1 | 6.20 |
| CHEMBL464859 | NECA | — | 1 | 6.00 |
| CHEMBL3770679 | — | — | 1 | 6.00 |
| CHEMBL3771208 | — | — | 1 | 5.80 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 5.60 |
| CHEMBL3770664 | — | — | 1 | 5.40 |
| CHEMBL3771290 | — | — | 1 | 4.80 |
| CHEMBL3771184 | — | — | 1 | 4.80 |
| CHEMBL3769641 | — | — | 1 | 4.00 |
| CHEMBL331372 | CGS-21680 | — | 1 | - |
| CHEMBL3769438 | — | — | 1 | - |
| CHEMBL3769408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284969 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3770310 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL116903 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL464859 | NECA | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3770679 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3771208 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL477 | ADENOSINE | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL3770664 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3771290 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL3771184 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL3769641 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL331372 | CGS-21680 | EC50 | = | 630957.34 | nM | - |
| CHEMBL3769438 | — | pEC50 | - | — | - | |
| CHEMBL3769408 | — | pEC50 | - | — | - |