Assay Detail
Binding
CHEMBL3772778
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Agonist activity at human Adenosine A2A receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 7 | - | - |
| EC50 | 6 | 5.24 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 6.47 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 5.24 |
| CHEMBL3770310 | — | — | 1 | 5.24 |
| CHEMBL284969 | — | — | 1 | 5.00 |
| CHEMBL3770679 | — | — | 1 | 4.80 |
| CHEMBL331372 | CGS-21680 | — | 1 | 4.70 |
| CHEMBL3771290 | — | — | 1 | - |
| CHEMBL3771208 | — | — | 1 | - |
| CHEMBL116903 | — | — | 1 | - |
| CHEMBL3770664 | — | — | 1 | - |
| CHEMBL3769641 | — | — | 1 | - |
| CHEMBL3771184 | — | — | 1 | - |
| CHEMBL3769416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL477 | ADENOSINE | EC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL3770310 | — | EC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL284969 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3770679 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL331372 | CGS-21680 | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3771290 | — | pEC50 | - | — | - | |
| CHEMBL3771208 | — | pEC50 | - | — | - | |
| CHEMBL116903 | — | pEC50 | - | — | - | |
| CHEMBL3770664 | — | pEC50 | - | — | - | |
| CHEMBL3769641 | — | pEC50 | - | — | - | |
| CHEMBL3771184 | — | pEC50 | - | — | - | |
| CHEMBL3769416 | — | pEC50 | - | — | - |