Assay Detail
Binding
CHEMBL3772809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N-acylethanolamine-hydrolyzing acid amidase (CHEMBL4349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.62 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770896 | — | — | 1 | 8.15 |
| CHEMBL3770525 | — | — | 1 | 7.92 |
| CHEMBL3771111 | — | — | 1 | 7.66 |
| CHEMBL3770726 | — | — | 1 | 7.57 |
| CHEMBL3769689 | — | — | 1 | 7.32 |
| CHEMBL3769678 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770896 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3770525 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3771111 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3770726 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3769689 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3769678 | — | IC50 | = | 76.0 | nM | 7.12 |