Assay Detail
Functional
CHEMBL3772893
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Antiviral activity against amantadine-resistant influenza A virus HN/1222 (H3N2) infected in dog MDCK cells assessed as inhibition of virus induced cytopathic effect after 40 hrs by Cell-Titer-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.94 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.45 |
| CHEMBL3770799 | — | — | 1 | 4.42 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | - |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3770799 | — | EC50 | = | 38490.0 | nM | 4.42 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | > | 200000.0 | nM | - |
| CHEMBL660 | AMANTADINE | EC50 | > | 20510.0 | nM | - |