Assay Detail
Functional
CHEMBL3772951
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Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.82 | 10.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770679 | — | — | 1 | 10.53 |
| CHEMBL464859 | NECA | — | 1 | 9.68 |
| CHEMBL3771184 | — | — | 1 | 9.40 |
| CHEMBL284969 | — | — | 1 | 9.30 |
| CHEMBL3771208 | — | — | 1 | 9.17 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 8.63 |
| CHEMBL3770664 | — | — | 1 | 8.54 |
| CHEMBL116903 | — | — | 1 | 8.36 |
| CHEMBL3770310 | — | — | 1 | 8.21 |
| CHEMBL3771290 | — | — | 1 | 7.72 |
| CHEMBL3769641 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770679 | — | IC50 | = | 0.02951 | nM | 10.53 |
| CHEMBL464859 | NECA | IC50 | = | 0.2089 | nM | 9.68 |
| CHEMBL3771184 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL284969 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3771208 | — | IC50 | = | 0.6761 | nM | 9.17 |
| CHEMBL477 | ADENOSINE | IC50 | = | 2.344 | nM | 8.63 |
| CHEMBL3770664 | — | IC50 | = | 2.884 | nM | 8.54 |
| CHEMBL116903 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL3770310 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL3771290 | — | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL3769641 | — | IC50 | = | 37.15 | nM | 7.43 |