Assay Detail
Binding
CHEMBL3772964
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Inhibition of KDM4A (unknown origin) by RFMS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.17 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770740 | — | — | 1 | 6.40 |
| CHEMBL1383671 | — | — | 1 | 6.30 |
| CHEMBL3771180 | — | — | 1 | 6.20 |
| CHEMBL3771198 | — | — | 1 | 6.20 |
| CHEMBL3769724 | — | — | 1 | 6.10 |
| CHEMBL3769511 | — | — | 1 | 5.80 |
| CHEMBL3770732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770740 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1383671 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3771180 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3771198 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3769724 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3769511 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3770732 | — | IC50 | > | 100000.0 | nM | - |