Assay Detail
Binding
CHEMBL3773067
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Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calmodulin-domain protein kinase 1 (CHEMBL1781862) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.80 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770299 | — | — | 1 | 8.34 |
| CHEMBL3771242 | — | — | 1 | 8.30 |
| CHEMBL3770425 | — | — | 1 | 8.30 |
| CHEMBL3770802 | — | — | 1 | 8.26 |
| CHEMBL3769459 | — | — | 1 | 8.22 |
| CHEMBL3770649 | — | — | 1 | 8.22 |
| CHEMBL3771306 | — | — | 1 | 8.22 |
| CHEMBL3770142 | — | — | 1 | 8.19 |
| CHEMBL3769798 | — | — | 1 | 8.15 |
| CHEMBL3770980 | — | — | 1 | 8.15 |
| CHEMBL3770409 | — | — | 1 | 8.10 |
| CHEMBL3771134 | — | — | 1 | 8.10 |
| CHEMBL3770760 | — | — | 1 | 8.10 |
| CHEMBL3770313 | — | — | 1 | 8.00 |
| CHEMBL3769623 | — | — | 1 | 7.96 |
| CHEMBL3770743 | — | — | 1 | 7.96 |
| CHEMBL3769990 | — | — | 1 | 7.92 |
| CHEMBL3769685 | — | — | 1 | 7.92 |
| CHEMBL3769900 | — | — | 1 | 7.89 |
| CHEMBL3769940 | — | — | 1 | 7.82 |
| CHEMBL3770632 | — | — | 1 | 7.80 |
| CHEMBL3770076 | — | — | 1 | 7.80 |
| CHEMBL3770546 | — | — | 1 | 7.80 |
| CHEMBL3771104 | — | — | 1 | 7.77 |
| CHEMBL3769570 | — | — | 1 | 7.70 |
| CHEMBL3769697 | — | — | 1 | 7.68 |
| CHEMBL3770340 | — | — | 1 | 7.58 |
| CHEMBL3770885 | — | — | 1 | 7.51 |
| CHEMBL3769918 | — | — | 1 | 7.51 |
| CHEMBL3771018 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770299 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3771242 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3770425 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3770802 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3769459 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3770649 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3771306 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3770142 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3769798 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3770980 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3770409 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3770760 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3771134 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3770313 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3770743 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3769623 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3769990 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3769685 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3769900 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3769940 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3770632 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3770076 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3770546 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3771104 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3769570 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3769697 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3770340 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3770885 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3769918 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3771018 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3770923 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3770676 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3770200 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3770662 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3770430 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3769980 | — | IC50 | = | 247.0 | nM | 6.61 |