Assay Detail
Binding
CHEMBL3773441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.52 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770049 | — | — | 1 | 6.75 |
| CHEMBL3771286 | — | — | 1 | 6.68 |
| CHEMBL3769991 | — | — | 1 | 6.58 |
| CHEMBL3770797 | — | — | 1 | 6.51 |
| CHEMBL3771296 | — | — | 1 | 6.50 |
| CHEMBL3771164 | — | — | 1 | 6.38 |
| CHEMBL3770903 | — | — | 1 | 6.36 |
| CHEMBL3770258 | — | — | 1 | 6.32 |
| CHEMBL3769999 | — | — | 1 | 6.27 |
| CHEMBL3771278 | — | — | 1 | 6.27 |
| CHEMBL3771012 | — | — | 1 | 5.88 |
| CHEMBL3770983 | — | — | 1 | 5.84 |
| CHEMBL3770654 | — | — | 1 | 5.79 |
| CHEMBL3769691 | — | — | 1 | 5.72 |
| CHEMBL3770429 | — | — | 1 | 5.72 |
| CHEMBL3770426 | — | — | 1 | 5.63 |
| CHEMBL3771035 | — | — | 1 | 5.47 |
| CHEMBL3769988 | — | — | 1 | 5.43 |
| CHEMBL3769677 | — | — | 1 | 5.33 |
| CHEMBL3769518 | — | — | 1 | 5.01 |
| CHEMBL3770872 | — | — | 1 | 4.84 |
| CHEMBL3770811 | — | — | 1 | 4.82 |
| CHEMBL3771302 | — | — | 1 | 4.78 |
| CHEMBL3769473 | — | — | 1 | 4.70 |
| CHEMBL3770731 | — | — | 1 | 4.51 |
| CHEMBL3770857 | — | — | 1 | 4.48 |
| CHEMBL3770860 | — | — | 1 | 4.48 |
| CHEMBL3770553 | — | — | 1 | 4.34 |
| CHEMBL3770486 | — | — | 1 | 4.19 |
| CHEMBL3770474 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770049 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3771286 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3769991 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3770797 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3771296 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3771164 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3770903 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3770258 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3769999 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3771278 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3771012 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3770983 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL3770654 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL3769691 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL3770429 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3770426 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL3771035 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3769988 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL3769677 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL3769518 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL3770872 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3770811 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3771302 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3769473 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3770731 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3770857 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3770860 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3770553 | — | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL3770486 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3770474 | — | IC50 | = | 77800.0 | nM | 4.11 |
| CHEMBL3769476 | — | IC50 | = | 127200.0 | nM | - |
| CHEMBL3771014 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3771167 | — | IC50 | = | 289000.0 | nM | - |
| CHEMBL3769737 | — | IC50 | = | 207000.0 | nM | - |
| CHEMBL3770074 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL3770610 | — | IC50 | = | 502800.0 | nM | - |
| CHEMBL3770257 | — | IC50 | = | 167700.0 | nM | - |
| CHEMBL3771179 | — | IC50 | = | 164500.0 | nM | - |