Assay Detail
Binding
CHEMBL3773707
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Inhibition of LPS induced NF-kappa-B transcriptional activity in mouse RAW264.7 cells after 20 hrs by SEAP reporter assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.06 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770894 | — | — | 1 | 5.77 |
| CHEMBL3770086 | — | — | 1 | 5.62 |
| CHEMBL3770543 | — | — | 1 | 5.62 |
| CHEMBL3770612 | — | — | 1 | 5.30 |
| CHEMBL3770883 | — | — | 1 | 5.22 |
| CHEMBL3770787 | — | — | 1 | 5.22 |
| CHEMBL3769950 | — | — | 1 | 5.05 |
| CHEMBL2041903 | — | — | 1 | 5.00 |
| CHEMBL3771221 | — | — | 1 | 5.00 |
| CHEMBL354972 | — | — | 1 | 5.00 |
| CHEMBL3771099 | — | — | 1 | 4.92 |
| CHEMBL549192 | — | — | 1 | 4.82 |
| CHEMBL3770564 | — | — | 1 | 4.79 |
| CHEMBL3770094 | — | — | 1 | 4.75 |
| CHEMBL355063 | BENDAZOL | 2.0 | 1 | 4.74 |
| CHEMBL1718693 | — | — | 1 | 4.72 |
| CHEMBL3770703 | — | — | 1 | 4.55 |
| CHEMBL233703 | — | — | 1 | - |
| CHEMBL3770693 | — | — | 1 | - |
| CHEMBL391352 | — | — | 1 | - |
| CHEMBL3770542 | — | — | 1 | - |
| CHEMBL1332026 | — | — | 1 | - |
| CHEMBL3769856 | — | — | 1 | - |
| CHEMBL3325832 | — | — | 1 | - |
| CHEMBL3771266 | — | — | 1 | - |
| CHEMBL153535 | — | — | 1 | - |
| CHEMBL3770254 | — | — | 1 | - |
| CHEMBL379179 | — | — | 1 | - |
| CHEMBL473163 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770894 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3770086 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3770543 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3770612 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3770883 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3770787 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3769950 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2041903 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3771221 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL354972 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3771099 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL549192 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3770564 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL3770094 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL355063 | BENDAZOL | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1718693 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3770703 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL233703 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3770693 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL391352 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3770542 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1332026 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3769856 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3325832 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3771266 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153535 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3770254 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL379179 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL473163 | — | IC50 | > | 30000.0 | nM | - |