Assay Detail
Binding
CHEMBL3773922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L-428 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.38 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431027 | — | — | 1 | 6.30 |
| CHEMBL1229516 | — | — | 1 | 5.30 |
| CHEMBL3770935 | — | — | 1 | 5.00 |
| CHEMBL3770688 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431027 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1229516 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3770935 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3770688 | — | IC50 | = | 12000.0 | nM | 4.92 |