Assay Detail
Functional
CHEMBL3776530
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Growth inhibition of human U87MG cells after 4 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.81 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774448 | — | — | 1 | 6.70 |
| CHEMBL568150 | — | — | 1 | 6.50 |
| CHEMBL3775393 | — | — | 1 | 6.25 |
| CHEMBL3774830 | — | — | 1 | 5.25 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | 5.14 |
| CHEMBL3775949 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774448 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL568150 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3775393 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3774830 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL269538 | HARMINE | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3775949 | — | IC50 | = | 9500.0 | nM | 5.02 |