Assay Detail
Binding
CHEMBL3776539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length N-terminal His-tagged human LSD2 (1 to 822 residues) expressed in Escherichia coli BL21(DE3) cells using H3K4me2 peptide substrate by MALDI-TOF mass spectrometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 2 (CHEMBL1938208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.88 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299307 | — | — | 1 | 5.12 |
| CHEMBL4299324 | — | — | 1 | 4.88 |
| CHEMBL4299278 | — | — | 1 | 4.63 |
| CHEMBL4299336 | — | — | 1 | - |
| CHEMBL4299338 | — | — | 1 | - |
| CHEMBL4299285 | — | — | 1 | - |
| CHEMBL4299296 | — | — | 1 | - |
| CHEMBL4299323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299307 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL4299324 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4299278 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4299336 | — | IC50 | - | — | - | |
| CHEMBL4299338 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4299285 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4299296 | — | IC50 | - | — | - | |
| CHEMBL4299323 | — | IC50 | - | — | - |