Assay Detail
Functional
CHEMBL3776566
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Cytotoxicity against human K562/G cells assessed as cell viability after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/G |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.73 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775684 | — | — | 1 | 7.33 |
| CHEMBL3774991 | — | — | 1 | 6.89 |
| CHEMBL3774592 | — | — | 1 | 6.64 |
| CHEMBL3775955 | — | — | 1 | 6.62 |
| CHEMBL3775355 | — | — | 1 | 6.24 |
| CHEMBL3775624 | — | — | 1 | 6.14 |
| CHEMBL3774614 | — | — | 1 | 6.00 |
| CHEMBL3774666 | — | — | 1 | 5.58 |
| CHEMBL3775644 | — | — | 1 | 5.57 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.33 |
| CHEMBL3775820 | — | — | 1 | 4.94 |
| CHEMBL3774976 | — | — | 1 | 4.82 |
| CHEMBL3775034 | — | — | 1 | 4.75 |
| CHEMBL3774958 | — | — | 1 | 4.71 |
| CHEMBL3775146 | — | — | 1 | 4.33 |
| CHEMBL3775914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775684 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3774991 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3774592 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3775955 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3775355 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3775624 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3774614 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3774666 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3775644 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL941 | IMATINIB | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL3775820 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3774976 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3775034 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL3774958 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3775146 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL3775914 | — | IC50 | > | 50000.0 | nM | - |