Assay Detail
Binding
CHEMBL3777310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counter
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.73 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 9.32 |
| CHEMBL78498 | — | — | 1 | 8.35 |
| CHEMBL150701 | — | — | 1 | 7.70 |
| CHEMBL151467 | — | — | 1 | 7.17 |
| CHEMBL154529 | — | — | 1 | 7.08 |
| CHEMBL153207 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | Ki | = | 0.4786 | nM | 9.32 |
| CHEMBL78498 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL150701 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL151467 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL154529 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL153207 | — | Ki | = | 181.97 | nM | 6.74 |