Assay Detail
Binding
CHEMBL3777356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-E2 from human ER-beta incubated for 16 to 20 hrs by liquid scintillation counting analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.93 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775016 | — | — | 1 | 7.40 |
| CHEMBL2137046 | — | — | 1 | 7.00 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.75 |
| CHEMBL3775434 | — | — | 1 | 6.58 |
| CHEMBL3774660 | — | — | 1 | - |
| CHEMBL3774647 | — | — | 1 | - |
| CHEMBL3775129 | — | — | 1 | - |
| CHEMBL3775006 | — | — | 1 | - |
| CHEMBL3775410 | — | — | 1 | - |
| CHEMBL3775224 | — | — | 1 | - |
| CHEMBL3775978 | — | — | 1 | - |
| CHEMBL3775283 | — | — | 1 | - |
| CHEMBL3775375 | — | — | 1 | - |
| CHEMBL3774642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775016 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2137046 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3775434 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3774660 | — | IC50 | - | — | - | |
| CHEMBL3774647 | — | IC50 | - | — | - | |
| CHEMBL3775129 | — | IC50 | - | — | - | |
| CHEMBL3775006 | — | IC50 | - | — | - | |
| CHEMBL3775410 | — | IC50 | - | — | - | |
| CHEMBL3775224 | — | IC50 | - | — | - | |
| CHEMBL3775978 | — | IC50 | - | — | - | |
| CHEMBL3775283 | — | IC50 | - | — | - | |
| CHEMBL3775375 | — | IC50 | - | — | - | |
| CHEMBL3774642 | — | IC50 | - | — | - |