Assay Detail
Binding
CHEMBL3777825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-M6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.13 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775796 | — | — | 1 | 9.74 |
| CHEMBL3774395 | — | — | 1 | 9.55 |
| CHEMBL4299340 | — | — | 1 | 9.46 |
| CHEMBL4299286 | — | — | 1 | 9.34 |
| CHEMBL4299295 | — | — | 1 | 9.32 |
| CHEMBL3775761 | — | — | 1 | 9.28 |
| CHEMBL3775192 | — | — | 1 | 9.23 |
| CHEMBL3774713 | — | — | 1 | 8.66 |
| CHEMBL4299313 | — | — | 1 | 8.46 |
| CHEMBL4299287 | — | — | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775796 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL3774395 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL4299340 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL4299286 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL4299295 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL3775761 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL3775192 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL3774713 | — | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL4299313 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4299287 | — | Ki | = | 5.94 | nM | 8.23 |