Assay Detail
Binding
CHEMBL3778246
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Inhibition of CK2 (unknown origin) using RRRDDDSDDD-NH2 as susbtrate incubated for 15 mins in presence of [gamma-32P]ATP
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.91 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568150 | — | — | 1 | 7.70 |
| CHEMBL3774448 | — | — | 1 | 7.40 |
| CHEMBL3775393 | — | — | 1 | 7.22 |
| CHEMBL3774830 | — | — | 1 | 7.00 |
| CHEMBL3774667 | — | — | 1 | 6.77 |
| CHEMBL3775949 | — | — | 1 | 6.66 |
| CHEMBL3775754 | — | — | 1 | 5.62 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | - |
| CHEMBL38043 | — | — | 1 | - |
| CHEMBL571292 | — | — | 1 | - |
| CHEMBL3193172 | — | — | 1 | - |
| CHEMBL3774696 | — | — | 1 | - |
| CHEMBL3774704 | — | — | 1 | - |
| CHEMBL3775111 | — | — | 1 | - |
| CHEMBL3775821 | — | — | 1 | - |
| CHEMBL3775969 | — | — | 1 | - |
| CHEMBL3774736 | — | — | 1 | - |
| CHEMBL3775193 | — | — | 1 | - |
| CHEMBL1612487 | — | — | 1 | - |
| CHEMBL3775538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568150 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3774448 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3775393 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3774830 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3774667 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3775949 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3775754 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL269538 | HARMINE | IC50 | - | — | - | |
| CHEMBL38043 | — | IC50 | - | — | - | |
| CHEMBL571292 | — | IC50 | - | — | - | |
| CHEMBL3193172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3774696 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3774704 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3775111 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3775821 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3775969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3774736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3775193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1612487 | — | IC50 | - | — | - | |
| CHEMBL3775538 | — | IC50 | > | 10000.0 | nM | - |