Compound Detail
CHEMBL3774667
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Basic Information
| ChEMBL ID | CHEMBL3774667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HGZJFYKLDIBVKD-TWGQIWQCSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
235.3
MW (Da)
2.02
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase II CHEMBL2095191 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Dual specificity protein kinase CLK1 CHEMBL4224 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B CHEMBL5543 | IC50 | 5.28 | 5.28 | 5200.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 2 CHEMBL4376 | IC50 | 5.04 | 5.04 | 9200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Casein kinase II | IC50 | = | 170.0 | nM | 6.77 | Inhibition of CK2 (unknown origin) using RRRDDDSDDD-NH2 as susbtrate incubated f... | 26896709 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of recombinant human N-terminal His6-tagged DYRK1A catalytic domain e... | 26896709 |
| Dual specificity protein kinase CLK1 | IC50 | = | 3600.0 | nM | 5.44 | Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 res... | 26896709 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | IC50 | = | 5200.0 | nM | 5.28 | Inhibition of full length recombinant human GST-tagged DYRK1B expressed in insec... | 26896709 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 2 | IC50 | = | 9200.0 | nM | 5.04 | Inhibition of recombinant human N-terminal GST-tagged DYRK2 expressed in Escheri... | 26896709 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Epidermal growth factor receptor | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Dual specificity protein kinase CLK1 | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Casein kinase II | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 26896709 | 10.1016/j.ejmech.2016.02.017 | Protein kinase C beta type | 1 |
Data from ChEMBL 36 via Core Engine