Assay Detail
Binding
CHEMBL3778288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Palmitoleoyl-protein carboxylesterase NOTUM (CHEMBL3714531) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.45 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774864 | — | — | 1 | 7.92 |
| CHEMBL3774760 | — | — | 1 | 7.68 |
| CHEMBL3775257 | — | — | 1 | 7.06 |
| CHEMBL3774528 | — | — | 1 | 6.97 |
| CHEMBL3775525 | — | — | 1 | 6.94 |
| CHEMBL3774472 | — | — | 1 | 6.84 |
| CHEMBL3775309 | — | — | 1 | 6.78 |
| CHEMBL3775700 | — | — | 1 | 6.68 |
| CHEMBL3775154 | — | — | 1 | 6.68 |
| CHEMBL3775791 | — | — | 1 | 6.60 |
| CHEMBL3775931 | — | — | 1 | 6.60 |
| CHEMBL3775182 | — | — | 1 | 6.55 |
| CHEMBL3775492 | — | — | 1 | 6.41 |
| CHEMBL3774544 | — | — | 1 | 6.40 |
| CHEMBL3775531 | — | — | 1 | 6.38 |
| CHEMBL3775413 | — | — | 1 | 6.36 |
| CHEMBL3775896 | — | — | 1 | 6.35 |
| CHEMBL3775859 | — | — | 1 | 6.32 |
| CHEMBL3775635 | — | — | 1 | 6.25 |
| CHEMBL1689356 | — | — | 1 | 6.24 |
| CHEMBL3774810 | — | — | 1 | 6.10 |
| CHEMBL3775731 | — | — | 1 | 6.08 |
| CHEMBL3775000 | — | — | 1 | 6.07 |
| CHEMBL3774802 | — | — | 1 | 6.05 |
| CHEMBL3774730 | — | — | 1 | 6.05 |
| CHEMBL3775407 | — | — | 1 | 5.83 |
| CHEMBL3774524 | — | — | 1 | 5.71 |
| CHEMBL3774745 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774864 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3774760 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3775257 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3774528 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3775525 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3774472 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3775309 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3775700 | — | EC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3775154 | — | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL3775791 | — | EC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3775931 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3775182 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3775492 | — | EC50 | = | 393.0 | nM | 6.41 |
| CHEMBL3774544 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3775531 | — | EC50 | = | 417.0 | nM | 6.38 |
| CHEMBL3775413 | — | EC50 | = | 435.0 | nM | 6.36 |
| CHEMBL3775896 | — | EC50 | = | 445.0 | nM | 6.35 |
| CHEMBL3775859 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL3775635 | — | EC50 | = | 556.0 | nM | 6.25 |
| CHEMBL1689356 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3774810 | — | EC50 | = | 789.0 | nM | 6.10 |
| CHEMBL3775731 | — | EC50 | = | 835.0 | nM | 6.08 |
| CHEMBL3775000 | — | EC50 | = | 857.0 | nM | 6.07 |
| CHEMBL3774802 | — | EC50 | = | 885.0 | nM | 6.05 |
| CHEMBL3774730 | — | EC50 | = | 881.0 | nM | 6.05 |
| CHEMBL3775407 | — | EC50 | = | 1462.0 | nM | 5.83 |
| CHEMBL3774524 | — | EC50 | = | 1965.0 | nM | 5.71 |
| CHEMBL3774745 | — | EC50 | = | 21928.0 | nM | 4.66 |