Assay Detail
Functional
CHEMBL3778482
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Antiproliferative activity against human A375 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774414 | — | — | 1 | 7.35 |
| CHEMBL3775521 | — | — | 1 | 6.67 |
| CHEMBL3774793 | — | — | 1 | 6.37 |
| CHEMBL3775581 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774414 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3775521 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3774793 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL3775581 | — | IC50 | = | 2851.0 | nM | 5.54 |