Assay Detail
Functional
CHEMBL3778688
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Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.66 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774414 | — | — | 1 | 7.66 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774414 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | > | 5000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 1000.0 | nM | - |