Assay Detail
Functional
CHEMBL3778916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CRF-R2 beta in rat A7r5 cells assessed as inhibition of rat Ucn1 induced cAMP accumulation after 30 mins by radioimmunoassay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | A7R5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 2 (CHEMBL3581) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.07 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299295 | — | — | 1 | 9.20 |
| CHEMBL3774395 | — | — | 1 | 9.11 |
| CHEMBL3774939 | — | — | 1 | 9.04 |
| CHEMBL3775796 | — | — | 1 | 9.00 |
| CHEMBL3775217 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299295 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3774395 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL3774939 | — | EC50 | = | 0.91 | nM | 9.04 |
| CHEMBL3775796 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3775217 | — | EC50 | = | 1.0 | nM | 9.00 |