Assay Detail
Binding
CHEMBL3778934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-M6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 9.14 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299295 | — | — | 1 | 9.80 |
| CHEMBL3774395 | — | — | 1 | 9.70 |
| CHEMBL4299341 | — | — | 1 | 9.70 |
| CHEMBL3774868 | — | — | 1 | 9.66 |
| CHEMBL3775030 | — | — | 1 | 9.62 |
| CHEMBL3774682 | — | — | 1 | 9.60 |
| CHEMBL4299349 | — | — | 1 | 9.54 |
| CHEMBL4299348 | — | — | 1 | 9.52 |
| CHEMBL3775796 | — | — | 1 | 9.51 |
| CHEMBL3775621 | — | — | 1 | 9.47 |
| CHEMBL3775678 | — | — | 1 | 9.38 |
| CHEMBL3775778 | — | — | 1 | 9.37 |
| CHEMBL4299352 | — | — | 1 | 9.35 |
| CHEMBL3775812 | — | — | 1 | 9.31 |
| CHEMBL3775437 | — | — | 1 | 9.31 |
| CHEMBL3774594 | — | — | 1 | 9.30 |
| CHEMBL4299308 | — | — | 1 | 9.28 |
| CHEMBL3774939 | — | — | 1 | 9.21 |
| CHEMBL3775761 | — | — | 1 | 9.19 |
| CHEMBL3774836 | — | — | 1 | 9.17 |
| CHEMBL3775192 | — | — | 1 | 9.17 |
| CHEMBL3774485 | — | — | 1 | 9.16 |
| CHEMBL3774742 | — | — | 1 | 9.16 |
| CHEMBL4299297 | — | — | 1 | 9.15 |
| CHEMBL3774465 | — | — | 1 | 9.13 |
| CHEMBL4299340 | — | — | 1 | 9.10 |
| CHEMBL4299286 | — | — | 1 | 9.10 |
| CHEMBL3774713 | — | — | 1 | 9.09 |
| CHEMBL4299335 | — | — | 1 | 9.04 |
| CHEMBL4299314 | — | — | 1 | 8.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299295 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL3774395 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4299341 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3774868 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3775030 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL3774682 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL4299349 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL4299348 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3775796 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL3775621 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL3775678 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL3775778 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL4299352 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL3775812 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL3775437 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL3774594 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4299308 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL3774939 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL3775761 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL3775192 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL3774836 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL3774485 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL3774742 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL4299297 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3774465 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL4299340 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL4299286 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL3774713 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL4299335 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL4299314 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL4299294 | — | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL4299355 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL4299313 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3775830 | — | Ki | = | 8.05 | nM | 8.09 |
| CHEMBL3775707 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL3775831 | — | Ki | = | 48.6 | nM | 7.31 |