Assay Detail
Functional
CHEMBL3779044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in mouse BV2 cells assessed as inhibition of LPS-stimulated TNFalpha production preincubated for 3 hrs followed by LPS treatment for 12 hrs by ELISA
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 2-piperidone derivatives for the inhibition of β-amyloid aggregation and inflammation mediated neurotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.28 | 7.70 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775246 | — | — | 2 | 7.70 |
| CHEMBL3775928 | — | — | 2 | 7.10 |
| CHEMBL3774597 | — | — | 2 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775246 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3775928 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3774597 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3775928 | — | Activity | - | — | - | |
| CHEMBL3775246 | — | Activity | - | — | - | |
| CHEMBL3774597 | — | Activity | - | — | - |