Assay Detail
Binding
CHEMBL3779260
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Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liquid scintillation counting
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.87 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 1 | 8.77 |
| CHEMBL3774686 | — | — | 1 | 8.52 |
| CHEMBL3775280 | — | — | 1 | 8.52 |
| CHEMBL3774873 | — | — | 1 | 8.52 |
| CHEMBL3775510 | — | — | 1 | 8.30 |
| CHEMBL3775430 | — | — | 1 | 8.05 |
| CHEMBL3774784 | — | — | 1 | 8.03 |
| CHEMBL3774706 | — | — | 1 | 8.00 |
| CHEMBL3774833 | — | — | 1 | 8.00 |
| CHEMBL3775979 | — | — | 1 | 7.96 |
| CHEMBL3774467 | — | — | 1 | 7.75 |
| CHEMBL3774941 | — | — | 1 | 7.64 |
| CHEMBL3774393 | — | — | 1 | 7.58 |
| CHEMBL3774805 | — | — | 1 | 7.57 |
| CHEMBL3775041 | — | — | 1 | 7.51 |
| CHEMBL3775676 | — | — | 1 | 7.46 |
| CHEMBL3775528 | — | — | 1 | 7.31 |
| CHEMBL3775360 | — | — | 1 | 7.28 |
| CHEMBL3775770 | — | — | 1 | 7.20 |
| CHEMBL3775475 | — | — | 1 | 7.17 |
| CHEMBL3774999 | — | — | 1 | 7.07 |
| CHEMBL3774586 | — | — | 1 | 7.05 |
| CHEMBL3775973 | — | — | 1 | 6.77 |
| CHEMBL3774541 | — | — | 1 | 6.44 |
| CHEMBL3775104 | — | — | 1 | 6.24 |
| CHEMBL3775610 | — | — | 1 | 5.66 |
| CHEMBL3774867 | — | — | 1 | 5.39 |
| CHEMBL3775392 | — | — | 1 | 5.38 |
| CHEMBL3775699 | — | — | 1 | 5.32 |
| CHEMBL3774439 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3774686 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3774873 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3775280 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3775510 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3775430 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3774784 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL3774706 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3774833 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3775979 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3774467 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3774941 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3774393 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3774805 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3775041 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3775676 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3775528 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3775360 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3775770 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3775475 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3774999 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3774586 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3775973 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3774541 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3775104 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3775610 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3774867 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3775392 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL3775699 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3774439 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3775462 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3774442 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3774754 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL3775954 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL3775653 | — | IC50 | = | 88400.0 | nM | 4.05 |
| CHEMBL3774572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774876 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563 | FLURBIPROFEN | IC50 | > | 100000.0 | nM | - |