Assay Detail
Functional
CHEMBL3782368
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Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.29 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.72 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.66 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.28 |
| CHEMBL3781424 | — | — | 1 | 5.09 |
| CHEMBL2337127 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3781424 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2337127 | — | IC50 | = | 20000.0 | nM | 4.70 |