Assay Detail
Functional
CHEMBL3782370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T84 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.30 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.92 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.52 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.21 |
| CHEMBL3781424 | — | — | 1 | 4.96 |
| CHEMBL2337127 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3781424 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2337127 | — | IC50 | = | 13000.0 | nM | 4.89 |