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Assay Detail

CHEMBL3782446

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MGC-803
Confidence 1 — Organism
Curated By Autocuration

Publication

Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects.
Xiao X, Ni Y, Jia YM, Zheng M, Xu HF, Xu J, Liao C.
Bioorg Med Chem Lett (2016) 26 : 1508 -1511
PubMed 26883149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 4.87 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3780654 1 5.54
CHEMBL185 FLUOROURACIL 4.0 1 5.47
CHEMBL3780734 1 5.44
CHEMBL3782024 1 5.37
CHEMBL3780176 1 5.16
CHEMBL3781973 1 4.98
CHEMBL3781288 1 4.91
CHEMBL3780568 1 4.81
CHEMBL3780399 1 4.69
CHEMBL3782027 1 4.65
CHEMBL3780707 1 4.52
CHEMBL3781523 1 4.45
CHEMBL3781107 1 4.42
CHEMBL3780625 1 4.42
CHEMBL3780016 1 4.28
CHEMBL3780881 1 -
CHEMBL3781152 1 -
CHEMBL3780786 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3780654 EC50 = 2890.0 nM 5.54
CHEMBL185 FLUOROURACIL EC50 = 3350.0 nM 5.47
CHEMBL3780734 EC50 = 3650.0 nM 5.44
CHEMBL3782024 EC50 = 4260.0 nM 5.37
CHEMBL3780176 EC50 = 6870.0 nM 5.16
CHEMBL3781973 EC50 = 10450.0 nM 4.98
CHEMBL3781288 EC50 = 12250.0 nM 4.91
CHEMBL3780568 EC50 = 15450.0 nM 4.81
CHEMBL3780399 EC50 = 20340.0 nM 4.69
CHEMBL3782027 EC50 = 22210.0 nM 4.65
CHEMBL3780707 EC50 = 30000.0 nM 4.52
CHEMBL3781523 EC50 = 35390.0 nM 4.45
CHEMBL3781107 EC50 = 38450.0 nM 4.42
CHEMBL3780625 EC50 = 37880.0 nM 4.42
CHEMBL3780016 EC50 = 52510.0 nM 4.28
CHEMBL3780881 EC50 > 60000.0 nM -
CHEMBL3781152 EC50 > 60000.0 nM -
CHEMBL3780786 EC50 > 60000.0 nM -