Assay Detail
Binding
CHEMBL3782567
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Inhibition of human GST tagged Tcf4/beta catenin interaction after 2 hrs using fluorescent AP Attophos substrate by ELISA analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.64 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780110 | — | — | 1 | 6.19 |
| CHEMBL578512 | — | — | 1 | 6.10 |
| CHEMBL179197 | — | — | 1 | 5.62 |
| CHEMBL261214 | — | — | 1 | 5.50 |
| CHEMBL2397075 | — | — | 1 | 5.39 |
| CHEMBL1080283 | CERCOSPORIN | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780110 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL578512 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL179197 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL261214 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2397075 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1080283 | CERCOSPORIN | IC50 | = | 8700.0 | nM | 5.06 |