TCF4-CTNNB1 complex · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P35222. Use UniProt P35222 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35222 as the stable identity anchor, then attach disease evidence before program review.
Catenin beta-1
Review this target as TCF4-CTNNB1 complex, mapped to UniProt P35222. ChEMBL maps the protein component as Catenin beta-1. Sequence length is 781 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats TCF4-CTNNB1 complex as ChEMBL target CHEMBL3885541, mapped to UniProt P35222. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | TCF4-CTNNB1 complex |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P35222 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Catenin beta-1 |
| UniProt Accession | P35222 |
| Component Type | Protein |
| Sequence Length | 781 aa |
Catenin beta-1
Review this target as TCF4-CTNNB1 complex, mapped to UniProt P35222. ChEMBL maps the protein component as Catenin beta-1. Sequence length is 781 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5285550 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL5274107 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL254381 | 6.35 | Kd | 450.0 | Preclinical |
| CHEMBL5436013 | 6.28 | IC50 | 530.0 | Preclinical |
| CHEMBL5189621 | 6.23 | IC50 | 583.0 | Preclinical |
| CHEMBL2397074 | 6.19 | IC50 | 640.0 | Preclinical |
| CHEMBL3780110 | 6.19 | IC50 | 640.0 | Preclinical |
| CHEMBL4451478 | 6.19 | Ki | 640.0 | Preclinical |
| CHEMBL578512 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL3260853 | 5.87 | Ki | 1360.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 21 | 30 | 5.6 |
| cell-based format | 10 | 13 | 5.3 |