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Assay Detail

CHEMBL3782597

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant factor 10a using H2N(EEdansyl)GKQLRVVNGG (KDabcyl)-NH2 as substrate by fluorometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.
Venukadasula PK, Owusu BY, Bansal N, Ross LJ, Hobrath JV, Bao D, Truss JW, Stackhouse M, Messick TE, Klampfer L, Galemmo RA.
ACS Med Chem Lett (2016) 7 : 177 -181
PubMed 26985294 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.95 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3780036 1 6.75
CHEMBL3780434 1 6.70
CHEMBL3780584 1 6.62
CHEMBL3781354 1 6.60
CHEMBL3781349 1 6.42
CHEMBL3779949 1 6.40
CHEMBL3780273 1 6.29
CHEMBL3780005 1 6.21
CHEMBL3781673 1 6.18
CHEMBL3780548 1 6.13
CHEMBL3781405 1 6.12
CHEMBL3781784 1 6.07
CHEMBL3780208 1 6.04
CHEMBL3781626 1 5.91
CHEMBL3780269 1 5.81
CHEMBL327254 1 5.27
CHEMBL3780039 1 4.64
CHEMBL3780437 1 4.59
CHEMBL3780277 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3780036 Ki = 180.0 nM 6.75
CHEMBL3780434 Ki = 200.0 nM 6.70
CHEMBL3780584 Ki = 240.0 nM 6.62
CHEMBL3781354 Ki = 250.0 nM 6.60
CHEMBL3781349 Ki = 380.0 nM 6.42
CHEMBL3779949 Ki = 400.0 nM 6.40
CHEMBL3780273 Ki = 510.0 nM 6.29
CHEMBL3780005 Ki = 610.0 nM 6.21
CHEMBL3781673 Ki = 660.0 nM 6.18
CHEMBL3780548 Ki = 740.0 nM 6.13
CHEMBL3781405 Ki = 750.0 nM 6.12
CHEMBL3781784 Ki = 850.0 nM 6.07
CHEMBL3780208 Ki = 920.0 nM 6.04
CHEMBL3781626 Ki = 1230.0 nM 5.91
CHEMBL3780269 Ki = 1550.0 nM 5.81
CHEMBL327254 Ki = 5400.0 nM 5.27
CHEMBL3780039 Ki = 22800.0 nM 4.64
CHEMBL3780437 Ki = 25500.0 nM 4.59
CHEMBL3780277 Ki = 49400.0 nM 4.31