Assay Detail
Binding
CHEMBL3782875
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Inhibition of KDM1B (unknown origin)
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 2 (CHEMBL1938208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.66 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781560 | — | — | 1 | 5.37 |
| CHEMBL3780774 | — | — | 1 | 5.37 |
| CHEMBL3780542 | — | — | 1 | 5.24 |
| CHEMBL3780674 | — | — | 1 | 4.94 |
| CHEMBL3780374 | — | — | 1 | 4.90 |
| CHEMBL3781885 | — | — | 1 | 4.83 |
| CHEMBL3781494 | — | — | 1 | 4.46 |
| CHEMBL3781125 | — | — | 2 | 4.44 |
| CHEMBL3781124 | — | — | 1 | 4.36 |
| CHEMBL3781751 | IADADEMSTAT | 2.0 | 1 | 4.36 |
| CHEMBL3780391 | — | — | 1 | 4.29 |
| CHEMBL3546846 | — | — | 1 | 4.23 |
| CHEMBL3781329 | — | — | 1 | 4.13 |
| CHEMBL3780524 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781560 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3780774 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3780542 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3780674 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3780374 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3781885 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3781494 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3781125 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL3781124 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL3781751 | IADADEMSTAT | IC50 | = | 43450.0 | nM | 4.36 |
| CHEMBL3781125 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL3780391 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3546846 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL3781329 | — | IC50 | = | 74700.0 | nM | 4.13 |
| CHEMBL3780524 | — | IC50 | - | — | - |