Assay Detail
Binding
CHEMBL3783006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.59 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181202 | — | — | 1 | 8.85 |
| CHEMBL3408519 | — | — | 1 | 8.73 |
| CHEMBL3781680 | — | — | 1 | 8.23 |
| CHEMBL1782141 | — | — | 1 | 8.07 |
| CHEMBL3781336 | — | — | 1 | 7.89 |
| CHEMBL3781519 | — | — | 1 | 7.69 |
| CHEMBL3780686 | — | — | 1 | 7.52 |
| CHEMBL3780820 | — | — | 1 | 7.15 |
| CHEMBL3780776 | — | — | 1 | 6.86 |
| CHEMBL3780818 | — | — | 1 | 6.27 |
| CHEMBL3780408 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181202 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL3408519 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL3781680 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1782141 | — | IC50 | = | 8.51 | nM | 8.07 |
| CHEMBL3781336 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3781519 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL3780686 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL3780820 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL3780776 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL3780818 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL3780408 | — | IC50 | = | 658.0 | nM | 6.18 |