Assay Detail
Binding
CHEMBL3783008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane after 2 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.64 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408519 | — | — | 1 | 10.10 |
| CHEMBL3781680 | — | — | 1 | 9.73 |
| CHEMBL1782141 | — | — | 1 | 9.38 |
| CHEMBL2181202 | — | — | 1 | 9.24 |
| CHEMBL3781519 | — | — | 1 | 8.93 |
| CHEMBL3781336 | — | — | 1 | 8.74 |
| CHEMBL3780686 | — | — | 1 | 8.51 |
| CHEMBL3780776 | — | — | 1 | 8.00 |
| CHEMBL3780818 | — | — | 1 | 7.70 |
| CHEMBL3780408 | — | — | 1 | 7.40 |
| CHEMBL3780820 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408519 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL3781680 | — | Ki | = | 0.187 | nM | 9.73 |
| CHEMBL1782141 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL2181202 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL3781519 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL3781336 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL3780686 | — | Ki | = | 3.07 | nM | 8.51 |
| CHEMBL3780776 | — | Ki | = | 9.91 | nM | 8.00 |
| CHEMBL3780818 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL3780408 | — | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL3780820 | — | Ki | = | 54.0 | nM | 7.27 |