Assay Detail
Functional
CHEMBL3783188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 2 hrs followed by LPS-stimulation for 4 hrs by sandwich ELISA relative to vehicle-treated control
51
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 30 | - | - |
| IC50 | 21 | 8.09 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781245 | — | — | 2 | 9.00 |
| CHEMBL3781473 | — | — | 2 | 8.70 |
| CHEMBL3780832 | — | — | 2 | 8.70 |
| CHEMBL3695568 | JNJ-49095397 | 2.0 | 2 | 8.40 |
| CHEMBL3781102 | — | — | 2 | 8.40 |
| CHEMBL3780714 | — | — | 2 | 8.40 |
| CHEMBL3781532 | — | — | 2 | 8.40 |
| CHEMBL3780154 | — | — | 2 | 8.40 |
| CHEMBL3780667 | — | — | 2 | 8.30 |
| CHEMBL3780519 | — | — | 2 | 8.30 |
| CHEMBL3781687 | — | — | 2 | 8.30 |
| CHEMBL3781413 | — | — | 2 | 8.30 |
| CHEMBL3781244 | — | — | 2 | 8.30 |
| CHEMBL3780386 | — | — | 2 | 8.22 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 2 | 7.82 |
| CHEMBL3781430 | — | — | 2 | 7.77 |
| CHEMBL3780410 | — | — | 2 | 7.64 |
| CHEMBL3781587 | — | — | 2 | 7.51 |
| CHEMBL3782009 | — | — | 2 | 7.43 |
| CHEMBL3780111 | — | — | 2 | 6.96 |
| CHEMBL3781982 | — | — | 2 | 6.54 |
| CHEMBL3781999 | — | — | 1 | - |
| CHEMBL3780629 | — | — | 1 | - |
| CHEMBL3780089 | — | — | 1 | - |
| CHEMBL3782036 | — | — | 1 | - |
| CHEMBL3780488 | — | — | 1 | - |
| CHEMBL143134 | — | — | 1 | - |
| CHEMBL343227 | — | — | 1 | - |
| CHEMBL3781528 | — | — | 1 | - |
| CHEMBL336001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781245 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3780832 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3781473 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3695568 | JNJ-49095397 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3781102 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3780714 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3781532 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3780154 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3780667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3781244 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3780519 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3781687 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3781413 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3780386 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3781430 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3780410 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3781587 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3782009 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3780111 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3781982 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL3781473 | — | Emax | = | 83.0 | % | - |
| CHEMBL3780154 | — | Emax | = | 80.0 | % | - |
| CHEMBL3780519 | — | Emax | = | 82.0 | % | - |
| CHEMBL3781687 | — | Emax | = | 90.0 | % | - |
| CHEMBL3781430 | — | Emax | = | 83.0 | % | - |
| CHEMBL3781102 | — | Emax | = | 93.0 | % | - |
| CHEMBL3780714 | — | Emax | = | 77.0 | % | - |
| CHEMBL3780488 | — | Emax | = | 42.0 | % | - |
| CHEMBL3781532 | — | Emax | = | 82.0 | % | - |
| CHEMBL3782036 | — | Emax | = | 42.0 | % | - |
| CHEMBL3781413 | — | Emax | = | 79.0 | % | - |
| CHEMBL3780410 | — | Emax | = | 77.0 | % | - |
| CHEMBL3782009 | — | Emax | = | 78.0 | % | - |
| CHEMBL3780629 | — | Emax | = | 33.0 | % | - |
| CHEMBL3781999 | — | Emax | = | 35.0 | % | - |
| CHEMBL3781982 | — | Emax | = | 60.0 | % | - |
| CHEMBL103667 | DORAMAPIMOD | Emax | = | 69.0 | % | - |
| CHEMBL3780386 | — | Emax | = | 72.0 | % | - |
| CHEMBL336001 | — | Emax | = | 45.0 | % | - |
| CHEMBL3695568 | JNJ-49095397 | Emax | = | 88.0 | % | - |
| CHEMBL3780111 | — | Emax | = | 60.0 | % | - |
| CHEMBL3780832 | — | Emax | = | 90.0 | % | - |
| CHEMBL343227 | — | Emax | = | 3.0 | % | - |
| CHEMBL3781245 | — | Emax | = | 95.0 | % | - |
| CHEMBL143134 | — | Emax | = | 51.0 | % | - |
| CHEMBL3780667 | — | Emax | = | 79.0 | % | - |
| CHEMBL3781587 | — | Emax | = | 74.0 | % | - |
| CHEMBL3781244 | — | Emax | = | 78.0 | % | - |
| CHEMBL3781528 | — | Emax | = | 16.0 | % | - |