Assay Detail
Binding
CHEMBL3783189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addition measured after 1 hr by Z-LYTE assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.89 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781244 | — | — | 1 | 9.00 |
| CHEMBL3781102 | — | — | 1 | 8.70 |
| CHEMBL3780667 | — | — | 1 | 8.70 |
| CHEMBL3781245 | — | — | 1 | 8.70 |
| CHEMBL3782036 | — | — | 1 | 8.52 |
| CHEMBL3695568 | JNJ-49095397 | 2.0 | 1 | 8.30 |
| CHEMBL3781687 | — | — | 1 | 8.22 |
| CHEMBL3781413 | — | — | 1 | 8.22 |
| CHEMBL3782009 | — | — | 1 | 8.22 |
| CHEMBL3780488 | — | — | 1 | 8.10 |
| CHEMBL3780832 | — | — | 1 | 8.10 |
| CHEMBL3781473 | — | — | 1 | 8.05 |
| CHEMBL3781430 | — | — | 1 | 7.96 |
| CHEMBL3780111 | — | — | 1 | 7.96 |
| CHEMBL343227 | — | — | 1 | 7.92 |
| CHEMBL3781532 | — | — | 1 | 7.89 |
| CHEMBL143134 | — | — | 1 | 7.77 |
| CHEMBL3780714 | — | — | 1 | 7.75 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.70 |
| CHEMBL336001 | — | — | 1 | 7.66 |
| CHEMBL3780519 | — | — | 1 | 7.62 |
| CHEMBL3780629 | — | — | 1 | 7.60 |
| CHEMBL3780386 | — | — | 1 | 7.57 |
| CHEMBL3780154 | — | — | 1 | 7.51 |
| CHEMBL3780089 | — | — | 1 | 7.48 |
| CHEMBL3781999 | — | — | 1 | 7.42 |
| CHEMBL3781982 | — | — | 1 | 7.28 |
| CHEMBL3781587 | — | — | 1 | 7.22 |
| CHEMBL3780410 | — | — | 1 | 6.91 |
| CHEMBL3781528 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781244 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3781102 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3780667 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3781245 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3782036 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3695568 | JNJ-49095397 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3781687 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3781413 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3782009 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3780488 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3780832 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3781473 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3781430 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3780111 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL343227 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3781532 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL143134 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3780714 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL336001 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3780519 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3780629 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3780386 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3780154 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3780089 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3781999 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3781982 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3781587 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3780410 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3781528 | — | IC50 | = | 167.0 | nM | 6.78 |