Assay Detail
Functional
CHEMBL3783190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in differentiated human U937 cells assessed as inhibition of LPS-induced of CXCL8 production preincubated for 2 hrs followed by LPS-stimulation for 4 hrs by sandwich ELISA relative to vehicle-treated control
50
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 30 | - | - |
| IC50 | 20 | 7.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781245 | — | — | 2 | 8.70 |
| CHEMBL3781473 | — | — | 2 | 8.52 |
| CHEMBL3780667 | — | — | 2 | 8.30 |
| CHEMBL3695568 | JNJ-49095397 | 2.0 | 2 | 8.15 |
| CHEMBL3780386 | — | — | 2 | 8.10 |
| CHEMBL3781982 | — | — | 2 | 8.05 |
| CHEMBL3780519 | — | — | 2 | 8.05 |
| CHEMBL3781687 | — | — | 2 | 8.05 |
| CHEMBL3781532 | — | — | 2 | 8.00 |
| CHEMBL3781102 | — | — | 2 | 7.92 |
| CHEMBL3781413 | — | — | 2 | 7.85 |
| CHEMBL3780832 | — | — | 2 | 7.82 |
| CHEMBL3780410 | — | — | 2 | 7.52 |
| CHEMBL3781587 | — | — | 2 | 7.50 |
| CHEMBL3780154 | — | — | 2 | 7.43 |
| CHEMBL3781244 | — | — | 2 | 7.43 |
| CHEMBL3780714 | — | — | 2 | 7.39 |
| CHEMBL3782009 | — | — | 2 | 7.06 |
| CHEMBL3781430 | — | — | 2 | 6.09 |
| CHEMBL3781999 | — | — | 2 | 5.80 |
| CHEMBL3780629 | — | — | 1 | - |
| CHEMBL3780089 | — | — | 1 | - |
| CHEMBL3782036 | — | — | 1 | - |
| CHEMBL143134 | — | — | 1 | - |
| CHEMBL3780488 | — | — | 1 | - |
| CHEMBL343227 | — | — | 1 | - |
| CHEMBL3781528 | — | — | 1 | - |
| CHEMBL336001 | — | — | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
| CHEMBL3780111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781245 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3781473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3780667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3695568 | JNJ-49095397 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3780386 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3781982 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3781687 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3780519 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3781532 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3781102 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3781413 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3780832 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3780410 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3781587 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3781244 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3780154 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3780714 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3782009 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3781430 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL3781999 | — | IC50 | = | 1581.0 | nM | 5.80 |
| CHEMBL3781982 | — | Emax | = | 75.0 | % | - |
| CHEMBL3781999 | — | Emax | = | 51.0 | % | - |
| CHEMBL103667 | DORAMAPIMOD | Emax | = | 56.0 | % | - |
| CHEMBL336001 | — | Emax | = | 28.0 | % | - |
| CHEMBL3781528 | — | Emax | = | 3.0 | % | - |
| CHEMBL343227 | — | Emax | = | -1.0 | % | - |
| CHEMBL3780410 | — | Emax | = | 64.0 | % | - |
| CHEMBL3781587 | — | Emax | = | 71.0 | % | - |
| CHEMBL3780111 | — | Emax | = | 46.0 | % | - |
| CHEMBL3781430 | — | Emax | = | 66.0 | % | - |
| CHEMBL3780488 | — | Emax | = | 46.0 | % | - |
| CHEMBL3782036 | — | Emax | = | 49.0 | % | - |
| CHEMBL3780154 | — | Emax | = | 76.0 | % | - |
| CHEMBL3780629 | — | Emax | = | 39.0 | % | - |
| CHEMBL3782009 | — | Emax | = | 60.0 | % | - |
| CHEMBL3780386 | — | Emax | = | 68.0 | % | - |
| CHEMBL3695568 | JNJ-49095397 | Emax | = | 88.0 | % | - |
| CHEMBL3780832 | — | Emax | = | 92.0 | % | - |
| CHEMBL143134 | — | Emax | = | 45.0 | % | - |
| CHEMBL3780519 | — | Emax | = | 80.0 | % | - |
| CHEMBL3781687 | — | Emax | = | 90.0 | % | - |
| CHEMBL3781244 | — | Emax | = | 94.0 | % | - |
| CHEMBL3781102 | — | Emax | = | 101.0 | % | - |
| CHEMBL3781473 | — | Emax | = | 74.0 | % | - |
| CHEMBL3780667 | — | Emax | = | 87.0 | % | - |
| CHEMBL3781532 | — | Emax | = | 76.0 | % | - |
| CHEMBL3781245 | — | Emax | = | 103.0 | % | - |
| CHEMBL3781413 | — | Emax | = | 63.0 | % | - |
| CHEMBL3780089 | — | Emax | = | 47.0 | % | - |
| CHEMBL3780714 | — | Emax | = | 65.0 | % | - |