Assay Detail
Binding
CHEMBL3783216
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Inhibition of human plasma kallikrein assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.75 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393386 | — | — | 1 | 7.62 |
| CHEMBL3781788 | — | — | 1 | 7.38 |
| CHEMBL3780324 | — | — | 1 | 6.26 |
| CHEMBL3781319 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393386 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3781788 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3780324 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL3781319 | — | Ki | = | 1850.0 | nM | 5.73 |