Assay Detail

CHEMBL3783330

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Functional

Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay

ChEMBL ↗

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Target

NCI-H460 (CHEMBL396) ↗

Open DB target context

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NCI-H460 (CHEMBL396) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H460

CHEMBL396

Anchored from Assay target.

Protein identity NCI-H460

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H460
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H460 (CHEMBL396) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Hydroxyurea derivatives of irofulven with improved antitumor efficacy.

Staake MD, Kashinatham A, McMorris TC, Estes LA, Kelner MJ.
Bioorg Med Chem Lett (2016) 26 : 1836 -1838
PubMed 26922141 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.65	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3781819	LP-184	1.0	1	8.00
CHEMBL118218	IROFULVEN	3.0	1	7.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3781819	LP-184	IC50	=	10.0	nM	8.00
CHEMBL118218	IROFULVEN	IC50	=	50.12	nM	7.30