Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3781819

LP-184
Phase I
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Phase I
CC1=C(CN(O)C(N)=O)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=C1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3781819
Name LP-184
Phase Phase I
Structure Type MOL
InChI Key VWMPVAZEBAKLFR-HNNXBMFYSA-N

Known Names

(-)-hydroxyurea methylacylfulvene Hydroxyurea methylacylfulvene Lp-184 LP184
25
Targets
54
Activities
1
Assay Types
0
PK Parameters
20
Publications
4
Known Names
1
Indications

Molecular Properties

304.4
MW (Da)
1.44
ALogP
4
HBA
3
HBD
103.9
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Extended Properties

Molecular Formula C16H20N2O4
MW 304.35
Aromatic Rings 0
Heavy Atoms 22
NP-Likeness 2.14

Indications

Neoplasms

Activity Summary

IC50 54 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
 IC50 8.0 7.096 10.0 30
A549
CHEMBL392
 IC50 8.0 8.0 10.0 1
NCI-H460
CHEMBL396
 IC50 8.0 8.0 10.0 1
NCI-H23
CHEMBL614997
 IC50 7.8 7.8 15.8 1
ACHN
CHEMBL614519
 IC50 7.5 7.5 31.6 1
A498
CHEMBL614516
 IC50 7.5 7.5 31.6 1
T47D
CHEMBL614361
 IC50 7.2 7.2 63.1 1
SK-MEL-5
CHEMBL614922
 IC50 7.2 7.2 63.1 1
NCI-H322M
CHEMBL614803
 IC50 7.0 7.0 100.0 1
Malme-3M
CHEMBL614021
 IC50 6.9 6.9 125.9 1
HT-29
CHEMBL384
 IC50 6.9 6.9 125.9 1
786-0
CHEMBL613102
 IC50 6.9 6.9 125.9 1
SK-MEL-28
CHEMBL614919
 IC50 6.9 6.9 125.9 1
U-251
CHEMBL615022
 IC50 6.9 6.9 125.9 1
M14
CHEMBL614317
 IC50 6.7 6.7 199.5 1
NCI-H226
CHEMBL614740
 IC50 6.7 6.7 199.5 1
MDA-MB-231
CHEMBL400
 IC50 6.6 6.6 251.2 1
SN12C
CHEMBL614054
 IC50 6.5 6.5 316.2 1
EKVX
CHEMBL614487
 IC50 6.5 6.5 316.2 1
MDA-MB-435
CHEMBL614697
 IC50 6.4 6.4 398.1 1
KM12
CHEMBL614709
 IC50 6.4 6.4 398.1 1
SK-MEL-2
CHEMBL614917
 IC50 6.4 6.4 398.1 1
NCI-H522
CHEMBL614387
 IC50 6.0 6.0 1000.0 1
MCF7
CHEMBL387
 IC50 5.9 5.9 1258.9 1
ADMET
CHEMBL612558
 IC50 5.06 5.06 8800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NCI-H460 IC50 = 10.0 nM 8.0 Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 10.0 nM 8.0 Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay 26922141
A549 IC50 = 10.0 nM 8.0 Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 12.59 nM 7.9 Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay 26922141
NCI-H23 IC50 = 15.85 nM 7.8 Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 15.85 nM 7.8 Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 19.95 nM 7.7 Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 19.95 nM 7.7 Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 25.12 nM 7.6 Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 25.12 nM 7.6 Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 25.12 nM 7.6 Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 25.12 nM 7.6 Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 25.12 nM 7.6 Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay 26922141
A498 IC50 = 31.62 nM 7.5 Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 31.62 nM 7.5 Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay 26922141
ACHN IC50 = 31.62 nM 7.5 Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 31.62 nM 7.5 Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 39.81 nM 7.4 Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 50.12 nM 7.3 Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay 26922141
NON-PROTEIN TARGET IC50 = 50.12 nM 7.3 Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay 26922141

Literature References

PubMed DOI Target Context # Activities
26922141 10.1016/j.bmcl.2016.02.028 NON-PROTEIN TARGET 31
26922141 10.1016/j.bmcl.2016.02.028 U-251 1
26922141 10.1016/j.bmcl.2016.02.028 Mus musculus 1
26922141 10.1016/j.bmcl.2016.02.028 ACHN 1
26922141 10.1016/j.bmcl.2016.02.028 A498 1
26922141 10.1016/j.bmcl.2016.02.028 786-0 1
26922141 10.1016/j.bmcl.2016.02.028 SK-MEL-5 1
26922141 10.1016/j.bmcl.2016.02.028 SK-MEL-28 1
26922141 10.1016/j.bmcl.2016.02.028 SK-MEL-2 1
26922141 10.1016/j.bmcl.2016.02.028 MDA-MB-435 1
26922141 10.1016/j.bmcl.2016.02.028 M14 1
26922141 10.1016/j.bmcl.2016.02.028 Malme-3M 1
26922141 10.1016/j.bmcl.2016.02.028 A549 1
26922141 10.1016/j.bmcl.2016.02.028 KM12 1
26922141 10.1016/j.bmcl.2016.02.028 HT-29 1
26922141 10.1016/j.bmcl.2016.02.028 NCI-H522 1
26922141 10.1016/j.bmcl.2016.02.028 NCI-H460 1
26922141 10.1016/j.bmcl.2016.02.028 NCI-H322M 1
26922141 10.1016/j.bmcl.2016.02.028 NCI-H23 1
26922141 10.1016/j.bmcl.2016.02.028 NCI-H226 1

Data from ChEMBL 36 via Core Engine