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Target Snapshot

CHEMBL614803 Target Snapshot

NCI-H322M · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
41,738Compounds
858Assays
17Approved Drugs
142.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H322M as ChEMBL target CHEMBL614803. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H322M
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614803
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H322M still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H322M
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H322M
UniProt AccessionN/A

NCI-H322M

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H322M.

Review nameNCI-H322M
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

17
Approved
3
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50142.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL38957 8.67 IC50 2.13 Preclinical
CHEMBL53463 7.52 IC50 30.0 Approved
CHEMBL325041 7.18 IC50 66.11 Clinical
CHEMBL1873475 7.0 IC50 100.0 Approved
CHEMBL3781819 7.0 IC50 100.0 Preclinical
CHEMBL5274027 6.96 IC50 110.0 Preclinical
CHEMBL5280123 6.96 IC50 110.0 Preclinical
CHEMBL41700 6.85 IC50 140.0 Preclinical
CHEMBL43453 6.77 IC50 170.0 Preclinical
CHEMBL1738758 6.74 IC50 183.0 Clinical
Distribution

pChEMBL Value Distribution

19
5.0
13
5.5
7
6.0
7
6.5
3
7.0
1
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

IBRUTINIB
CHEMBL1873475
Approved 2013
Properties Compare Identifier
AMSACRINE
CHEMBL43
Approved 1987
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

858
Total Assays
131
Tested Compounds
2
Assay Types
Functional — 851 assays, 131 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 851 131 5.3
ADME — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine