Assay Detail
Functional
CHEMBL3783536
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Antiparasitic activity against suramin-sensitive trypomastigote stage of Trypanosoma brucei rhodesiense squib-427 infected in human MRC5 cells after 4 days by Alamar blue staining based fluorimetric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.70 |
| CHEMBL3291243 | — | — | 1 | 5.10 |
| CHEMBL3291242 | — | — | 1 | 4.57 |
| CHEMBL3780605 | — | — | 1 | 4.54 |
| CHEMBL3781870 | — | — | 1 | 4.52 |
| CHEMBL3781446 | — | — | 1 | 4.49 |
| CHEMBL1946739 | — | — | 1 | 4.49 |
| CHEMBL1946740 | — | — | 1 | 4.49 |
| CHEMBL3780946 | — | — | 1 | 4.49 |
| CHEMBL3781706 | — | — | 1 | 4.49 |
| CHEMBL3291250 | — | — | 1 | 4.48 |
| CHEMBL3781420 | — | — | 1 | 4.47 |
| CHEMBL3291241 | — | — | 1 | - |
| CHEMBL3780620 | — | — | 1 | - |
| CHEMBL3780819 | — | — | 1 | - |
| CHEMBL3781877 | — | — | 1 | - |
| CHEMBL3291249 | — | — | 1 | - |
| CHEMBL3780533 | — | — | 1 | - |
| CHEMBL3780260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3291243 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3291242 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL3780605 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3781870 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL3781446 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL1946739 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL1946740 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL3780946 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL3781706 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL3291250 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL3781420 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL3291241 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3780620 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3780819 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3781877 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3291249 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3780533 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3780260 | — | IC50 | > | 64000.0 | nM | - |