Assay Detail
Functional
CHEMBL3783780
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Antiproliferative activity against human A375 cells after 48 hrs by Cell titer blue viability assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.56 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780087 | — | — | 1 | 4.82 |
| CHEMBL3781822 | — | — | 1 | 4.30 |
| CHEMBL3781059 | — | — | 1 | - |
| CHEMBL3780576 | — | — | 1 | - |
| CHEMBL3781188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780087 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3781822 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3781059 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL3780576 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL3781188 | — | IC50 | = | 300000.0 | nM | - |