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Assay Detail

CHEMBL3784402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiferroptotic activity in human IMR32 neuroblastoma cells assessed as inhibition of erastin-induced cell death preincubated for 1 hr before erastin stimulation and measured after 13 hrs by fluorescence plate reader method
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type IMR-32
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties.
Hofmans S, Vanden Berghe T, Devisscher L, Hassannia B, Lyssens S, Joossens J, Van Der Veken P, Vandenabeele P, Augustyns K.
J Med Chem (2016) 59 : 2041 -2053
PubMed 26696014 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 7.83 8.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3780061 1 8.62
CHEMBL3779992 1 8.52
CHEMBL3780314 1 8.47
CHEMBL3781878 1 8.47
CHEMBL3781262 1 8.46
CHEMBL3781944 1 8.43
CHEMBL3781803 1 8.41
CHEMBL3781002 1 8.40
CHEMBL3779907 1 8.31
CHEMBL3781212 1 8.28
CHEMBL3781144 1 8.22
CHEMBL3780800 1 8.21
CHEMBL3780356 1 8.19
CHEMBL3781080 1 8.19
CHEMBL3781237 1 8.09
CHEMBL3780790 1 8.03
CHEMBL3780318 1 8.03
CHEMBL3780068 1 7.96
CHEMBL3781834 1 7.96
CHEMBL3781091 1 7.85
CHEMBL3781732 1 7.82
CHEMBL3780745 1 7.77
CHEMBL3633556 1 7.75
CHEMBL3780393 1 7.68
CHEMBL3781740 1 7.66
CHEMBL3781509 1 7.64
CHEMBL3780995 1 7.58
CHEMBL3781908 1 7.57
CHEMBL3781748 1 7.55
CHEMBL3780692 1 7.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3780061 IC50 = 2.4 nM 8.62
CHEMBL3779992 IC50 = 3.0 nM 8.52
CHEMBL3781878 IC50 = 3.4 nM 8.47
CHEMBL3780314 IC50 = 3.4 nM 8.47
CHEMBL3781262 IC50 = 3.5 nM 8.46
CHEMBL3781944 IC50 = 3.7 nM 8.43
CHEMBL3781803 IC50 = 3.9 nM 8.41
CHEMBL3781002 IC50 = 4.0 nM 8.40
CHEMBL3779907 IC50 = 4.9 nM 8.31
CHEMBL3781212 IC50 = 5.2 nM 8.28
CHEMBL3781144 IC50 = 6.0 nM 8.22
CHEMBL3780800 IC50 = 6.2 nM 8.21
CHEMBL3780356 IC50 = 6.4 nM 8.19
CHEMBL3781080 IC50 = 6.5 nM 8.19
CHEMBL3781237 IC50 = 8.2 nM 8.09
CHEMBL3780790 IC50 = 9.3 nM 8.03
CHEMBL3780318 IC50 = 9.4 nM 8.03
CHEMBL3780068 IC50 = 11.0 nM 7.96
CHEMBL3781834 IC50 = 11.0 nM 7.96
CHEMBL3781091 IC50 = 14.0 nM 7.85
CHEMBL3781732 IC50 = 15.0 nM 7.82
CHEMBL3780745 IC50 = 17.0 nM 7.77
CHEMBL3633556 IC50 = 18.0 nM 7.75
CHEMBL3780393 IC50 = 21.0 nM 7.68
CHEMBL3781740 IC50 = 22.0 nM 7.66
CHEMBL3781509 IC50 = 23.0 nM 7.64
CHEMBL3780995 IC50 = 26.0 nM 7.58
CHEMBL3781908 IC50 = 27.0 nM 7.57
CHEMBL3781748 IC50 = 28.0 nM 7.55
CHEMBL3780692 IC50 = 34.0 nM 7.47
CHEMBL3780062 IC50 = 36.0 nM 7.44
CHEMBL3781429 IC50 = 61.0 nM 7.21
CHEMBL3780064 IC50 = 67.0 nM 7.17
CHEMBL3780195 IC50 = 76.0 nM 7.12
CHEMBL3781416 IC50 = 76.0 nM 7.12
CHEMBL3781992 IC50 = 82.0 nM 7.09
CHEMBL3782040 IC50 = 88.0 nM 7.06
CHEMBL3781172 IC50 = 128.0 nM 6.89
CHEMBL3781698 IC50 = 210.0 nM 6.68