Assay Detail
Binding
CHEMBL3784463
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Inhibition of human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-Gln-H substrate measured for 15 mins by spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory effect of flavonoids on human glutaminyl cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.70 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201747 | — | — | 1 | 5.28 |
| CHEMBL3780265 | — | — | 1 | 4.85 |
| CHEMBL3780826 | — | — | 1 | 4.82 |
| CHEMBL3781389 | — | — | 1 | 4.82 |
| CHEMBL3781227 | — | — | 1 | 4.79 |
| CHEMBL3781737 | — | — | 1 | 4.78 |
| CHEMBL3781605 | — | — | 1 | 4.71 |
| CHEMBL3780173 | — | — | 1 | 4.58 |
| CHEMBL3780401 | — | — | 1 | 4.55 |
| CHEMBL59589 | — | — | 1 | 4.46 |
| CHEMBL3780601 | — | — | 1 | 4.43 |
| CHEMBL294878 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201747 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3780265 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3780826 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3781389 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3781227 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL3781737 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3781605 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL3780173 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3780401 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL59589 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL3780601 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL294878 | — | IC50 | = | 45200.0 | nM | 4.34 |