Assay Detail
Binding
CHEMBL3784478
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Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten equation analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.86 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398612 | — | — | 1 | 9.51 |
| CHEMBL3781742 | — | — | 1 | 8.62 |
| CHEMBL3780342 | — | — | 1 | 8.62 |
| CHEMBL3781202 | — | — | 1 | 8.49 |
| CHEMBL3780324 | — | — | 1 | 8.43 |
| CHEMBL3780922 | — | — | 1 | 8.42 |
| CHEMBL3781553 | — | — | 1 | 8.28 |
| CHEMBL3781788 | — | — | 1 | 8.20 |
| CHEMBL3398642 | — | — | 1 | 8.17 |
| CHEMBL3781363 | — | — | 1 | 8.17 |
| CHEMBL3393386 | — | — | 1 | 8.14 |
| CHEMBL3780189 | — | — | 1 | 8.12 |
| CHEMBL3780777 | — | — | 1 | 8.10 |
| CHEMBL3780030 | — | — | 1 | 8.08 |
| CHEMBL3781550 | — | — | 1 | 8.04 |
| CHEMBL3780285 | — | — | 1 | 8.04 |
| CHEMBL3781505 | — | — | 1 | 8.00 |
| CHEMBL3780001 | — | — | 1 | 7.96 |
| CHEMBL3781580 | — | — | 1 | 7.92 |
| CHEMBL3393385 | — | — | 1 | 7.89 |
| CHEMBL3780127 | — | — | 1 | 7.77 |
| CHEMBL3781319 | — | — | 1 | 7.64 |
| CHEMBL3781277 | — | — | 1 | 7.62 |
| CHEMBL3780751 | — | — | 1 | 7.28 |
| CHEMBL3781981 | — | — | 1 | 7.25 |
| CHEMBL3780930 | — | — | 1 | 7.21 |
| CHEMBL3780501 | — | — | 1 | 7.06 |
| CHEMBL3781679 | — | — | 1 | 7.06 |
| CHEMBL3781581 | — | — | 1 | 7.01 |
| CHEMBL3781691 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398612 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL3781742 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3780342 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3781202 | — | Ki | = | 3.197 | nM | 8.49 |
| CHEMBL3780324 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3780922 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3781553 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL3781788 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL3398642 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3781363 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3393386 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL3780189 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL3780777 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL3780030 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL3780285 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3781550 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL3781505 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3780001 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3781580 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3393385 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3780127 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3781319 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3781277 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3780751 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3781981 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3780930 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL3780501 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3781679 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3781581 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL3781691 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3781468 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL3780389 | — | Ki | = | 205.0 | nM | 6.69 |